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目的 针对风湿性心瓣膜炎的早期诊断 ,建立一项检测抗心瓣膜蛋白抗体的方法 ,并探讨其临床意义。方法 采用ELISA法检测抗心瓣膜蛋白抗体 (AVP) ,比较 30例风湿性心瓣膜炎、31例风湿性心脏病、2 4例风湿性关节炎和 40名正常人血清中AVP水平 ,并与抗链球菌多糖抗体(ASP)、红细胞沉降率 (ESR)及C反应蛋白 (CRP)作一对比。结果 风湿性心瓣膜炎组AVP水平高于其他三个组 (P <0 0 5 ) ,风湿性心脏病静止组高于后两个组 (P <0 0 5 ) ,而后两组间差异无显著性(P >0 0 5 )。风湿性心瓣膜炎组AVP阳性率高于ESR及CRP。风湿性关节炎组AVP阳性率低于ASP阳性率。结论 AVP具有判断风湿性心瓣膜炎的临床价值 ,且具有较ESR、CRP敏感性高的优点。
Objective To establish a new method to detect anti-valvular protein antibody in early diagnosis of rheumatic valvular heart disease and to explore its clinical significance. Methods The anti-valvular protein antibody (AVP) was detected by ELISA. The serum levels of AVP in 30 rheumatic heart valves, 31 rheumatic heart diseases, 24 rheumatoid arthritis and 40 normal controls were compared. Streptococcus polysaccharide antibody (ASP), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for a comparison. Results The level of AVP in patients with rheumatic valvular heart disease was significantly higher than those in the other three groups (P <0.05), those in still group with rheumatic heart disease were higher than those in the latter two groups (P <0 05), but no significant difference was found between the two groups Sex (P> 0.05). The positive rate of AVP in rheumatic valvulitis group was higher than ESR and CRP. The positive rate of AVP in rheumatoid arthritis group was lower than that of ASP. Conclusion AVP has the clinical value of judging rheumatic valvular heart disease, and has the advantages of high sensitivity compared with ESR and CRP.