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本文报告32例慢粒患者原始细胞危象(BC)时末端去氧核苷酸转移酶(TdT)的活性问题并比较TdT(+)组和(-)组患者的临床特点。男21,女11,年龄11～78岁(中数42),所有患者均有Ph~1染色体。 32例中22例原始细胞TdT活性(-),其中21例原始细胞类似原始粒细胞;10例TdT(+),其中9例原始细胞类似原始淋巴细胞。两组细胞E玫瑰花结和膜表面免疫球蛋白均(-)。BC时,两组血红蛋白几乎相同。(+)组60％和(-)组20％的患者白细胞>11×10~4。(+)组40％和(-)组65％的患者,血小板>101×10~3,(-)组有30％患者血小板>301×10~3。TdT(-)组过氧化酶染色,原始细胞6例
This article reports 32 patients with chronic myeloid leukemia (BC) terminal deoxynucleotidyl transferase (TdT) activity problems and compared TdT (+) and (-) group of patients with clinical features. Male 21, female 11, aged 11 to 78 years (median 42), all patients have Ph ~ 1 chromosome. TdT activity (-) was detected in 22 cases of primitive cells in 32 cases (21 cases). Among them, 21 cases of primordial cells resembled primitive granulocytes and 10 cases of TdT (+). Among them, 9 cases of primordial cells resembled primitive lymphocytes. Both groups of E-rosettes and membrane-surface immunoglobulins were (-). BC, the two groups of hemoglobin is almost the same. 60% of the patients in the (+) group and 20% of the patients in the (-) group had leukocytes> 11 × 10 ~ 4. 40% of the patients in the (+) group and 65% of the patients in the (-) group had platelets> 101 × 10-3, and 30% of the patients in the (-) group had platelets> 301 × 10-3. TdT (-) group peroxidase staining, 6 cases of primitive cells