论文部分内容阅读
目的：测定芬太尼静脉麻醉对血浆ｃＡＭＰ、ｃＧＭＰ含量的影响。方法：应用微量输液泵对３３例行择期上腹部手术病人诱导后持续恒定静脉内输入芬太尼，３组剂量分别为：Ⅰ组２５（μｇ·ｋｇ－１·ｈ－１，ｎ＝１２）；Ⅱ组５（μｇ·ｋｇ－１·ｈ－１，ｎ＝１３）；Ⅲ组７５（μｇ·ｋｇ－１·ｈ－１，ｎ＝８），芬太尼静脉输入到手术缝皮后停止。分诱导前（Ｔ１）、气管插管后（Ｔ２）、手术７０ｍｎ时（Ｔ３）、术终（Ｔ４）４次采静脉血，用放射免疫法测定ｃＡＭＰ、ｃＧＭＰ含量。结果：插管后、手术７０ｍｉｎ时及术终与术前比较ｃＡＭＰ、ｃＧＭＰ的含量均无显著差异（Ｐ＞００５）；组间比较Ｔ４时段ｃＡＭＰ值Ⅲ组较Ⅰ组，ｃＧＭＰ值Ⅱ组、Ⅲ组较Ⅰ组有显著性降低（Ｐ＜００５）。结论：芬太尼可有效地抑制血浆ｃＡＭＰ、ｃＧＭＰ的含量升高。
Objective: To determine the effect of fentanyl intravenous anesthesia on plasma cAMP and cGMP contents. Methods: Thirty-three patients undergoing elective upper abdominal surgery were treated with continuous infusion of fentanyl for a sustained and constant dose of intravenous infusion. The three doses were as follows: group Ⅰ 2.5 (μg · kg -1 · h -1, n = 12), group 5 (μg · kg-1 · h-1, n = 13), group Ⅲ (group 75 μg · kg-1 · h-1, n = 8) Stop sewing after skinning Before induction (T1), tracheal intubation (T2), 70mn (T3) and T4 (T4) venous blood were collected 4 times, and the contents of cAMP and cGMP were measured by radioimmunoassay. Results: After intubation, there were no significant differences in cAMP and cGMP contents between the end of operation and the end of operation (P> 005) at 70 min and at the end of operation. Compared with group Ⅰ, cGMP value of group Ⅲ , And that in group Ⅲ was significantly lower than that in group Ⅰ (P <005). Conclusion: Fentanyl can effectively inhibit the increase of plasma cAMP and cGMP levels.