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目的：建立一种快速稳定的杏仁核电刺激点燃癫?模型。方法：选取SD雄性大鼠40只制作杏仁核点燃癫?模型，按随机化原则分为5组：A 组为空白对照组；B组刺激频率16 Hz ，波宽1．0ms、强度0．5mA，串长10个；C组刺激频率16Hz、波宽1．0ms，强度0．5mA，串长160个；D组刺激频率60Hz，波宽1．0ms，强度0．5mA，串长10个；E组采用刺激频率60Hz，波宽1．0ms，强度0．5mA，串长160个进行实验。利用这种不同频率、强度、串长电刺激杏仁核的模式寻找出最快速有效且稳定的点燃癫?模型的方法。结果：在全部大鼠中成功点燃23只（点燃成功率为72％），然而在4种不同电刺激方法中，B组、C组、D组、E组的点燃成功率分别为100％、87％、87％和11％，B组与各组及组间比较差异有统计学意义（P＜0．01）。结论：本实验大鼠杏仁核电刺激可快速建立癫?模型，采用刺激频率16Hz、波宽1．0ms、强度0．5mA、串长10个的刺激参数，杏仁核快速点燃的效果最好。“,”Objective:To establish a rapid and stable amygdala kindling model of epilepsy .Methods:Forty SD male rats were selected to establish an amygdala kindling model of epilepsy .The rats were ran‐domly divided into 5 groups .Group A was the blank control group .Both Group B and Group C adopted the same stimulus frequencies of 16 Hz ,wave space of 1 .0 ms and intensity of 0 .5 mA .The only differ‐ence was the string length ,10 and 160 for Group B and Group C respectively .Similarly ,both Group D and Group E adopted the same stimulus frequency of 60 Hz ,wave length of 1 .0 ms and intensity of 0 .5 mA . Again the only difference was the string length ,l0 and 160 for Group D and Group E respectively .The aim was to find out the most rapid ,effective and stable method by using different stimulus frequency ,in‐tensity and string length to stimulate the amygdala .Results:Of all rats ,23 of them were successfully kin‐dled ,with a success rate of 72% .While among four different electric‐stimulated methods ,the success rate for Group B ,Group C ,Group D and Group E was 100% ,87% ,87% and 11% respectively .The differ‐ences between Group B and other groups and the differences within all the groups were of statistical sig‐nificance(P<0 .01) .Conclusion:The electric stimulation of amygdala in rats could can help establish a model of epilepsy .Adopting the parameters of Group B(stimulus frequency :16 Hz ,wave space of 1 .0 ms , intensity of 0 .5 mA ,duration:10 ms ,amygdala was rapidly kindled ,and the best results can be achieled .