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【目的】通过对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者应用小剂量茶碱后,肺功能、6min步行试验(six-minute walking distance,6MWD)等指标的检测,探讨小剂量茶碱对COPD患者的预后影响。【方法】应用前瞻、随机分组、对照及自身对照的方法,将1 252例稳定期COPD患者(Ⅱ～Ⅲ级)分为治疗组(茶碱缓释片0.4 g/d)和对照组(安慰剂);对应用茶碱治疗前后的各项指标进行统计学比较。【结果】(1)治疗组的稳定期COPD患者经过75 d的治疗,在用药前后第1 s用力呼气容积实测值与预计值的百分比(FEV1%prep)及FEV1和用力肺活量实测值与预计值的百分比(FEV1/FVC%)较对照组明显升高(P<0.05)。(2)稳定期COPD患者的治疗组与对照组比较,治疗后治疗组的6MWD比对照组增加5.3个月,但结果无统计学意义(P>0.05)。(3)治疗组患者的年内平均感染次数为2.45次/人,对照组年内感染次数为2.99次/人,两者无统计学差异(P>0.05)。【结论】应用小剂量氨茶碱可改善稳定期COPD患者的肺功能,可能会提高患者的运动耐力、降低年内感染次数。
【Objective】 To investigate the effect of low-dose theophylline on lung function, 6-minute walking distance (6MWD) and other indicators in patients with stable chronic obstructive pulmonary disease (COPD) Effect of Dose Theophylline on the Prognosis of COPD Patients. 【Methods】 A total of 1,252 patients with stable COPD (grade Ⅱ ~ Ⅲ) were divided into treatment group (theophylline sustained-release tablets 0.4 g / d) and control group (prospective, randomized, controlled and self- Agent); the use of theophylline before and after treatment of the indicators for statistical comparison. 【Results】 (1) The stable COPD patients in the treatment group after 75 days of treatment, the measured and predicted FEV1% prep of forced expiratory volume 1 s before and after treatment and FEV1 and forced vital capacity measured and predicted The percentage of value (FEV1 / FVC%) was significantly higher than that of the control group (P <0.05). (2) Compared with the control group, the treatment group with stable COPD had a 6MWD increase of 5.3 months compared with the control group, but the result was not statistically significant (P> 0.05). (3) In the treatment group, the average number of infections in the year was 2.45 times per person, while that in the control group was 2.99 times / person during the year. There was no significant difference between the two groups (P> 0.05). 【Conclusion】 The application of low-dose aminophylline can improve lung function in patients with stable COPD, which may improve exercise endurance and reduce the number of infections during the year.