论文部分内容阅读
目的探讨中国西南地区人群中,OATP1B1基因多态性与抗结核药物导致肝损害的遗传易感风险的关联性。方法用Taqman基因分型法对抗结核药物治疗后患者OATP1B1基因388A>G、521T>C位点进行分型,并统计分析OATP1B1基因多态性与抗结核药所致肝损害之间的关系。结果 380例服用抗结核药物患者纳入研究,对其进行Hardy-Weinberg(H-W)平衡检验,经检验达H-W平衡。抗结核药物导致肝损害组195例,未导致肝损害组185例,在筛选出的2个多肽位点中(388A>G,521T>C),521T>C位点与抗结核药所致肝损伤有相关(P=0.04),进一步排除年龄因素后,该位点仍与抗结核药所致肝损伤具有相关性(P=0.02)。结论 OATP1B1基因521T>C位点与抗结核药物肝损害存在相关性,其可能成为抗结核药肝损害风险预测的候选基因。
Objective To investigate the association of genetic polymorphisms of OATP1B1 with genetic susceptibility to liver damage caused by antituberculosis drugs in Southwest China. Methods The 388A> G and 521T> C loci of OATP1B1 gene were genotyped by Taqman genotyping and the relationship between OATP1B1 gene polymorphism and anti - TB drug - induced liver injury was analyzed. Results 380 patients taking anti-TB drugs were included in the study, and their Hardy-Weinberg (H-W) balance test, the test up to H-W balance. 195 cases of liver damage caused by anti-tuberculosis drugs and 185 cases of non-liver damage caused by hepatitis B virus (388A> G, 521T> C) and 521T> C (P = 0.04). After further exclusion of age, the site was still associated with anti-TB drug-induced liver injury (P = 0.02). Conclusion There is a correlation between 521T> C locus of OATP1B1 gene and liver damage of antituberculosis drugs, which may be a candidate gene for predicting the risk of liver damage of antituberculosis drugs.