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目的:比较不同粒径的碳酸钙在体外模拟胃肠道环境中的除铅效果。方法:原子吸收光谱仪测定Pb2+浓度。结果:碳酸钙在模拟胃液中Pb2+没有影响,在pH 6.0模拟肠液中具有除铅效果,除铅效果随碳酸钙粒径减小而增强。结论:碳酸钙粒径对除铅效果有影响,将纳米碳酸钙制备成肠溶生物粘附制剂,可以通过阻断铅的肠肝循环,成为新型驱铅药物。
OBJECTIVE: To compare the effects of different sizes of calcium carbonate on lead removal in gastrointestinal tract in vitro. Methods: Determination of Pb2 + concentration by atomic absorption spectrometry. Results: Calcium carbonate had no effect on Pb2 + in simulated gastric fluid, and had the effect of removing lead in simulated intestinal fluid at pH 6.0. The effect of lead removal increased with the decrease of calcium carbonate particle size. CONCLUSION: The particle size of calcium carbonate has effect on lead removal. The preparation of enteric bioadhesive preparation of nano-CaCO3 can become a new lead-removing drug by blocking the enterohepatic circulation of lead.