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目的观察α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变(DPN)的临床疗效。方法选取2013年9月-2014年11月医院住院治疗的DPN患者60例,随机分为观察组和对照组各30例。观察组采用α-硫辛酸+甲钴胺治疗,对照组采用甲钴胺治疗。观察2组患者的临床治疗效果及治疗前后神经传导速度的变化。结果观察组总有效率为90.0%高于对照组的73.3%,差异有统计学意义(P<0.05);治疗后2组TCSS评分明显降低,神经传导速度(NCV)均增加,上述指标观察组优于对照组,差异有统计学意义(P<0.05)。结论α-硫辛酸联合甲钴胺治疗DPN疗效确切。
Objective To observe the clinical efficacy of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods Sixty DPN patients hospitalized from September 2013 to November 2014 in our hospital were randomly divided into observation group (30 cases) and control group (30 cases). The observation group was treated with α-lipoic acid and mecobalamin, while the control group was treated with methylcobalamin. The clinical efficacy and the changes of nerve conduction velocity before and after treatment in two groups were observed. Results The total effective rate in the observation group was 90.0%, which was significantly higher than that in the control group (73.3%) (P <0.05). The TCSS score and the nerve conduction velocity (NCV) Better than the control group, the difference was statistically significant (P <0.05). Conclusion α-lipoic acid combined with mecobalamin for the treatment of DPN is effective.