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1976年一种T细胞生长因子被首次发现,是以有丝分裂原刺激淋巴细胞而产生的。这一物质可以维持激活了的T细胞增殖而做为抗原接触后的第二刺激物。其后证实了具有特异功能的T淋巴细胞在体外反复接触这种物质后可以克隆扩增方式生长。此后,有关T细胞生长因子的大量知识相继被人们认识并将之改名为白间素Ⅱ(IL-2)。近年来由于基因工程技术的发展,IL-2已可通过合成的方式大量生产,称之为重组白间素Ⅱ(Recombinant In-
In 1976, a T cell growth factor was discovered for the first time and was produced by mitogen stimulation of lymphocytes. This substance can maintain the proliferation of activated T cells as a second stimulant after antigen exposure. Subsequently, it was confirmed that T-lymphocytes with specific functions can be grown in clonal fashion after repeated contact with this substance in vitro. Since then, a great deal of knowledge about T-cell growth factors has been recognized and renamed Interleukin II (IL-2). In recent years, due to the development of genetic engineering technology, IL-2 has been produced in large quantities through synthetic methods. It is called recombinant interleukin II (Recombinant In-