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[目的]探讨Livin、Beclin-1在子宫内膜癌中的表达及其临床意义。[方法]选择各类子宫内膜组织蜡块143例。以免疫组化法检测Livin和Beclin-1的表达并分析其与组织学分级、临床分期以及淋巴结转移等的关系。[结果]Livin和Beclin-1表达在不同子宫内膜癌组织中差异均有统计学意义(P<0.05)。Livin和Beclin-1表达与组织学分级和肌层浸润有关(P<0.05),而与FIGO分期和淋巴结转移无关(P>0.05)。[结论 ]Livin和Beclin-1在子宫内膜癌发生和演化及浸润转移中可能起重要作用。
[Objective] To investigate the expression of Livin and Beclin-1 in endometrial carcinoma and its clinical significance. [Method] Select all kinds of endometrial paraffin block 143 cases. The expression of Livin and Beclin-1 was detected by immunohistochemistry and their relationship with histological grade, clinical stage and lymph node metastasis were analyzed. [Results] The expressions of Livin and Beclin-1 in different endometrial carcinoma tissues were significantly different (P <0.05). The expression of Livin and Beclin-1 was correlated with histological grade and myometrial invasion (P <0.05), but not with FIGO stage and lymph node metastasis (P> 0.05). [Conclusion] Livin and Beclin-1 may play an important role in the occurrence, evolution and invasion and metastasis of endometrial carcinoma.