最近发现全反式维甲酸（ATRA）与a一干扰素（IFN－a）合用有抑制实体瘤恶性细胞生长的作用。作者研究了ATRA是否能增强IFN－a对慢性髓性白血病（CML）的白血病细胞增殖的抑制。病人和方法16例新确诊慢性期CML病人，细胞遗传学分析100％分裂中期细胞Ph1染色体阳性。治疗前采取血 It was recently discovered that the combination of all-trans retinoic acid (ATRA) and a-interferon (IFN-a) inhibits the growth of malignant cells in solid tumors. The authors investigated whether ATRA can enhance IFN-α inhibition of leukemia cell proliferation in chronic myelogenous leukemia (CML). Patients and Methods Sixteen newly diagnosed chronic phase CML patients were cytogenetically analyzed for 100% metaphase metaphase cells with Ph1 chromosome positive. Take blood before treatment