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有关双碘喹啉(Ⅰ)和氯碘喹啉(Ⅱ)的测定的已有方法都存在操作繁琐、费时或仪器昂贵等缺点。作者根据英国药典(1968)关于醋碘苯酸钠注射液的测定法加以改进,介绍一个简易准确、适用于原药也适用于其制剂的新测定法,实验操作如下:(1)Ⅰ的测定:准确秤取样品约0.3克,置于250毫升锥形瓶中,加锌粉约0.5克和15%NaOH30毫升,回流加热30分钟,先以 NaOH 液5毫升,再用少量蒸馏水冲洗冷凝管和烧瓶壁,去掉冷凝管后,继
The existing methods for the determination of diiodoquinoline (I) and chloroiodoquinoline (II) all have the disadvantages of cumbersome operation, time-consuming or expensive equipment. According to the British Pharmacopoeia (1968) on the determination of sodium acetate injection to be improved, a simple and accurate, suitable for the original drug also applies to the preparation of a new assay, the experimental operation is as follows: (1) Determination of Ⅰ : Accurately weighed sample of about 0.3 grams, placed in 250 ml Erlenmeyer flask, add about 0.5 grams of zinc and 15% NaOH30 ml, reflux heating for 30 minutes, first NaOH solution 5 ml, and then a small amount of distilled water flush condenser and Flask, remove the condenser, follow