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目的探讨吸烟导致心脑血管病发病增加的机理。方法从人体指标着手,对52名健康男性吸烟者的血小板粘附率和100名健康男性吸烟者的血液粘度、血沉及红细胞压积进行测定,并与健康男性非吸烟者进行配对比较。统计方法采用t检验和方差分析。结果吸烟组血小板粘附率(69.89+15.57)显著高于非吸烟组(33.82+17.96)(P<0.01);吸烟年限越长血小板粘附率越高[吸烟年限<11年(63.63+16.23)%;11~20年(71.61+14.35)%;>20年(81.13+11.59)%]。吸烟组每个切变率的血液粘度均显著高于非吸烟组(P<0.05);但在吸烟者中,各年龄组间及各吸烟年限组间的血液粘度差异无显著性(P>0.05)。吸烟组的血沉及红细胞压积与非吸烟组间差异无显著性(P>0.05)。结论吸烟可显著增加血小板粘附率及血液粘度,从而改变吸烟者的血液流变学。
Objective To explore the mechanism of cigarette smoking leading to increased incidence of cardiovascular and cerebrovascular diseases. Methods Starting from the human body indexes, the platelet adhesion rate of 52 healthy male smokers and the blood viscosity, erythrocyte sedimentation rate and hematocrit of 100 healthy male smokers were measured and compared with healthy male non-smokers. Statistical methods using t test and analysis of variance. Results The rate of platelet adhesion in smoking group was significantly higher than that in non-smoking group (69.89 + 15.57 vs 33.82 + 17.96, P <0.01). The longer the smoking period, the higher the rate of platelet adhesion [smoking duration <11 years (63.63 + 16.23) %; 11-20 years (71.61 + 14.35%);> 20 years (81.13 + 11.59)%]. The blood viscosity at each shear rate in the smoking group was significantly higher than that in the non-smoking group (P <0.05), but there was no significant difference in the viscosity of blood among all age groups and smoking groups (P> 0.05 ). There were no significant differences in ESR, hematocrit and non-smoking group (P> 0.05). Conclusion Smoking can significantly increase the rate of platelet adhesion and blood viscosity, thus changing the blood rheology of smokers.