美国糖尿病学会(ADA)2013年会上公布的一项涉及10,163例患者的最新分析显示,胰岛素剂量并不会增加ACCORD关键性研究中2型糖尿病患者心血管(CV)死亡。在未校正的风险模型中,每日胰岛素剂量增加1U/kg体重可将心血管死亡风险提高0.8～2.4倍。然而,在后续4个模型中对一系列基线和治疗期间的协变量进行校正后,发现胰岛素剂量与CV死亡之间并无关联。 A recent analysis of 10,163 patients published at the American Diabetes Association’s (ADA) 2013 meeting showed that insulin doses did not increase cardiovascular death in patients with type 2 diabetes in ACCORD’s pivotal study. In uncorrected risk models, increasing 1U / kg daily insulin dose increased the risk of cardiovascular death by 0.8-2.4 times. However, after adjusting for a series of baseline and covariates during treatment in the subsequent 4 models, there was no correlation between insulin dose and CV death.