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本实验观察了阻断冠脉血流后血液流变学的变化并分析了肾上腺髓质活动增强在急性心肌缺血早期血液流变学变化中的作用。实验结果表明,对照组阻断冠脉血流40min时全血粘度已显著增加,血细胞压积、血浆纤维蛋白原浓度逐渐升高。阻断冠脉血流前切断双侧内脏大神经可消除心肌缺血早期血液流变学的异常变化,而切断内脏大神经后输注肾上腺素又可使心肌缺血时全血粘度、血细胞压积等各项指标出现明显异常。上述结果提示,阻断冠脉血流后交感-肾上腺系统活动增强可能是急性心肌缺血早期血液流变学变化的重要原因。
This experiment observed changes in blood rheology after blocking coronary blood flow and analyzed the role of increased adrenal medulla activity in hemorheology at the early stage of acute myocardial ischemia. The experimental results show that the control group blocked the coronary blood flow 40min when the whole blood viscosity has increased significantly, hematocrit, plasma fibrinogen concentration gradually increased. Blockade of coronary blood flow before the cut off of bilateral visceral nerve can eliminate abnormal changes of early blood rheology of myocardial ischemia, and cut off the visceral nerve adrenergic infusion can make myocardial ischemia whole blood viscosity, hematocrit Product and other indicators showed obvious abnormalities. The above results suggest that the increased sympathetic-adrenal system blockade after coronary blood flow may be an important cause of early hemorheological changes in acute myocardial ischemia.