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药理学抑郁病的原因仍未阐明,越来越多的证据表明它可能是边缘系统内去甲肾上腺素和5-羟色胺(5 HT)功能缺乏所致。内源性抑郁症可能与去甲肾上腺素能的传递异常有关,而反应性抑郁症与5HT传递异常有关,很多抗抑新郁药主要作用于5HT传递,然而,抑郁症可能也与胆碱活性增强及细胞间钠浓缩增加有关。据证实,抗抑郁新药如洛非帕明(lofepramine)、fluvoxamine和氟西丁(f1uoxetine)过量时也较安全。总之,它们副作用比老药少,药效快。
The cause of pharmacological depression is still unknown, and there is growing evidence that it may be due to the lack of norepinephrine and serotonin (5 HT) function in the limbic system. Endogenous depression may be associated with noradrenergic transmission abnormalities, and reactive depression and 5HT transmission abnormalities, many anti-depressive drugs mainly act on 5HT transmission, however, depression may also be associated with cholinergic activity Enhancement and increased intercellular sodium concentration related. It has also been shown that new antidepressant drugs such as lofepramine, fluvoxamine and f1uoxetine are also safer. In short, they have fewer side effects than the old drugs and have a quick efficacy.