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目的探讨精神发育迟滞患者的认知电位P300与智力残疾之间的关系。方法按中国精神障碍分类与诊断标准第3版(CCMD-3)中精神发育迟滞诊断标准,收集60例精神发育迟滞患者(精神发育迟滞组),适应行为评定量表进行智力残疾程度评定,并进行认知电位P300检测,与40例正常者(对照组)进行比较。结果 1精神发育迟滞组P300潜伏期(584.58±149.72)ms较对照组(332.65±37.78)ms显著延长(P<0.01),P300波幅降低(P<0.01)。2经Pearson相关分析,适应行为评定量表总分与P300潜伏期正向相关(r=0.405,P<0.05)。结论 P300可作为精神发育迟滞患者认知功能受损以及判断其社会适应功能状况的指标之一。
Objective To investigate the relationship between cognitive impairment (P300) and mental retardation in patients with mental retardation. Methods According to the diagnosis standard of mental retardation in the third edition (CCMD-3) of Chinese mental disorder, 60 cases of mental retardation (mental retardation group) were collected, and the scale of mental retardation was assessed according to the behavioral assessment scale P300 detection of cognitive potential, and 40 normal controls (control group) were compared. Results The P300 latency (584.58 ± 149.72) ms in mental retardation group was significantly longer than that in control group (332.65 ± 37.78 ms) (P <0.01), while P300 amplitude was lower (P <0.01). 2 Pearson correlation analysis showed that the total score of adaptive behavior assessment scale positively correlated with P300 latency (r = 0.405, P <0.05). Conclusions P300 can be used as one of the indicators of impaired cognitive function and social function in patients with mental retardation.