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目的：建立一种戊四氮（ＰＴＺ） 致癫癎状态（ＳＥ） 模型，并探讨ＰＴＺ 致惊厥与癫癎形成之间的关系。方法：观察ＰＴＺ 致抽搐发作（ 抽搐组） 和ＰＴＺ致抽搐延长发作即癫癎状态（ＳＥ 组） 对大鼠长期行为和脑电（ＥＥＧ） 的影响，同时观察二者是否产生海马、皮质神经元损伤。结果：ＰＴＺ 致抽搐延长发作能够产生具有某些癫癎特征的长期效应，如自发癎样放电、惊厥阈下剂量ＰＴＺ 可诱导癫癎发作以及皮质和海马神经元损伤，而单次抽搐发作不具有这些长期效应。结论：ＰＴＺ 致抽搐延长发作模型更符合ＳＥ 模型特点，惊厥持续时间与癫癎形成密切相关。
OBJECTIVE: To establish a PTZ-induced epileptic state (SE) model and to investigate the relationship between PTZ-induced convulsion and epilepsy. Methods: The long-term behavior and electroencephalogram (EEG) were observed in seizure-induced (convulsive) and PTZ-induced seizure-induced (PT) epileptic seizures (SE group). The hippocampus and cortical neurons damage. RESULTS: Prolonged PTZ-induced seizures produced long-term effects with certain epileptic characteristics such as spontaneous discharge, subliminal seizure PTZ induced epileptic seizures and cortical and hippocampal neuronal damage, whereas seizures without single seizures did not have These long-term effects. CONCLUSION: The prolonged seizure model induced by PTZ is more consistent with the characteristics of SE model. The duration of seizure is closely related to the formation of epilepsy.