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利用染石英尘大鼠作为实验模型，比较支气管肺泡冲洗液（ＢＡＬＦ）、肺泡巨噬细胞（ＡＭ）中脂质过氧化产物和抗氧化物质的动态变化．结果表明，石英可以诱发ＡＭ脂质过氧化，在ＢＡＬＦ和ＡＭ中脂质过氧化产物（ＬＰＯ）的变化呈一致的趋势，但抗氧化物质的变化不完全相同．超氧化物歧化酶（ＳＯＤ）在ＢＡＬＦ和ＡＭ中活性均降低，说明石英可使其ＡＭ内该酶大量消耗或对该酶的活性有抑制作用．而还原型谷膛甘肽（ＧＳＨ）和谷胱甘肽过氧化物酶在ＡＭ内降低，但在ＢＡＬＦ中升高，说明石英对这两项指标无直接的影响，在ＡＭ内的降低是与从细胞内外漏入肺泡有关．
In this study, the dynamic changes of lipid peroxidation products and antioxidant substances in bronchoalveolar lavage fluid (BALF) and alveolar macrophages (AM) were compared using quartz-dyed rats as experimental models. The results showed that quartz could induce AM lipid peroxidation. The changes of lipid peroxidation products (LPO) in BALF and AM showed a consistent trend, but the changes of antioxidants did not exactly the same. The activity of superoxide dismutase (SOD) decreased in both BALF and AM, indicating that quartz can make the enzyme in AM consume a large amount of it or inhibit the activity of the enzyme. While reduced glutathione (GSH) and glutathione peroxidase decreased in AM but increased in BALF, indicating that quartz had no direct effect on these two parameters and that reduction in AM was associated with Leakage from the cell into the alveoli-related.