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心房肽类物质是由猪心房组织中提取的多肽混合物。初步试验证明,该类物质对豚鼠心肌特性有一定影响。作者观察了该制剂对心律失常模型的影响及其急性毒性和致敏作用。结果表明,该制剂对小鼠氯仿,小鼠氯化钡诱发的心律失常有明显的对抗作用。对大鼠乌头碱诱发的心律失常对抗作用较弱;该制剂对动物几乎无毒性和致敏作用。
Atrial peptides are mixtures of peptides extracted from pig atrial tissue. Preliminary tests have shown that these substances have a certain influence on the myocardial properties of guinea pigs. The authors observed the effect of the preparation on the arrhythmia model and its acute toxicity and sensitization. The results showed that the preparation had obvious antagonistic effects on the arrhythmia induced by chloroform and mouse cesium chloride. The arrhythmia-evoked arrhythmia induced by rat aconitine was weaker; the preparation had almost no toxicity and sensitization to animals.