乳腺癌最易发生骨转移(75%),患者生存时间短,仅为2年。骨转移最常见的症状是骨并发症和骨痛,严重影响患者的生存质量。乳腺癌骨转移中存在着“邪恶循环”:肿瘤细胞释放甲状旁腺激素相关蛋白等促进破骨细胞活性,从而造成骨质破坏;而骨质吸收破坏后可释放出生长因子,又进一步促进 Breast cancer most likely to have bone metastases (75%), patients with short survival time, only 2 years. The most common symptoms of bone metastases are bone complications and bone pain, seriously affecting the quality of life in patients. Bone metastasis of breast cancer there is a “vicious cycle”: tumor cells release parathyroid hormone-related proteins and other promote osteoclast activity, resulting in bone destruction; and destruction of bone can release growth factors, and then further promote