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目的建立超声多普勒测量颈-股脉搏波传播速度(PWV)的方法,明确大动脉炎(TA)患者大动脉僵硬度的变化情况,探讨基于超声多普勒的PWV评价在TA中的价值。方法纳入首次诊治的TA女性患者23例,并招募同期健康对照组女性志愿者23例,年龄、身高、体质量与病例组匹配。所有受试者颈-股PWV的测量采用超声多普勒法。结果 TA患者的颈-股PWV与健康对照组相比显著增加[(8.66±2.12)m/s vs(6.51±1.11)m/s,P<0.001]。结论 TA患者超声多普勒法测量的中心动脉僵硬度较正常人群显著增高,表明TA患者存在显著的大血管病变。基于超声多普勒的颈-股PWV评价为临床监测和评价中心动脉僵硬度和心血管风险提供了一项重要的方法和指标。
Objective To establish a method for measuring neck-to-femoral pulse wave velocity (PWV) by using Doppler echocardiography, and to determine the change of aortic stiffness in patients with aortic arterial inflammation (TA) and to evaluate the value of PWV evaluation based on ultrasound Doppler in TA. Methods Twenty-three female TA patients were recruited for the first time. Twenty-three female volunteers were enrolled in the same period. The age, height, body weight and case group were matched. The cervical-femoral PWV was measured by ultrasound Doppler in all subjects. Results The cervical-femoral PWV in patients with TA was significantly higher than that in healthy controls [(8.66 ± 2.12) m / s vs (6.51 ± 1.11) m / s, P <0.001). Conclusions The central artery stiffness measured by Doppler ultrasound in TA patients is significantly higher than that in normal subjects, indicating that there is a significant macrovascular disease in patients with TA. The assessment of cervical-femoral PWV based on Doppler ultrasound provides an important method and index for clinical monitoring and evaluation of central arterial stiffness and cardiovascular risk.