性腺发育不全症及泛发性白总癜风临床上并非罕见,但两者并发尚未见报道,我们遇到1例报告如下.患者女,26岁.1994年10月15日就诊.14岁发现左腹部一小黑痣色素自行消退,以后其周围有一继发性白斑,范围逐渐扩大,延及整个胸背四肢,无自觉症状.24岁全身正常色素均消失.头发眉毛根部变白.一年前面部双前臂日晒后有点状色素沉着斑,至今无月经来潮.饮食及大小便正常.父母非近亲结婚,否认家族中有类似发病者,包括患者弟弟.患者母亲因腰椎结核,在怀孕该患之前一年用过异烟肼、链霉素等,直至该患出生后,经手术治疗腰椎结核痊愈.怀孕其弟时已不再应用抗结核药.体检:外表女性,身高1.45cm,声音低 Gonadal hypoplasia and generalized vitiligo is not uncommon in clinical practice, but the two have not been reported concurrently, and we have encountered one case report as follows. Female patient, 26 years old. On October 15, 1994, 14 years old found that A small mole on the left abdomen pigment subsides itself, after which there is a secondary leukoplakia, the scope gradually expanded, extending to the entire chest and back limbs, no symptoms .24 year old normal body pigment disappear. Frontal forearm after sun exposure a bit like pigmentation spots, so that no menstrual cramps. Normal diet and urine. Married non-relatives of parents, denied the family have a similar incidence, including patients brother. Patient mother of lumbar tuberculosis, during pregnancy Suffering from the previous year used isoniazid, streptomycin, etc., until the patient is born, after surgical treatment of lumbar tuberculosis healed .Then their younger brother is no longer anti-tuberculosis drugs. Physical examination: Female appearance, height 1.45cm, the sound low