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用氢化可的松3．6mg／kg，给大鼠灌胃，每周6次，1个月后改为每周2次，制成类固醇性骨质疏松动物模型，研究黄芪抗骨质疏松的作用。黄芪水提液5g／kg灌胃，每周6次，持续60d。不脱钙骨制片，用图象定量法，对大鼠胫骨近端骨小梁骨代谢的静、动态指标进行测算。结果：a）激素组骨吸收增加261％，骨形成减少63％，骨小梁面积减少23％。b）黄艺加激素组与a）比，骨吸收减69％，骨形成率增加100％，骨小梁面积增加27％，提示黄芪能防治类固醇性骨质疏松。
The rats were given intragastric administration with hydrocortisone 3.6 mg/kg, 6 times per week, 1 week later, 2 times per week, and a steroid-induced osteoporosis animal model was established to study the anti-osteoporosis effect of Astragalus membranaceus. effect. Astragalus water extract 5 g/kg gavage, 6 times a week for 60d. Without decalcification bone preparation, the static and dynamic indicators of bone metabolism in the proximal humerus of rat were measured by image quantitative method. Results: a) In the hormone group, the bone resorption increased by 261%, the bone formation decreased by 63%, and the trabecular bone area decreased by 23%. b) Compared with the a) ratio of Huangyi plus hormone group, bone resorption decreased by 69%, bone formation rate increased by 100%, and bone trabecular area increased by 27%, suggesting that Huangqi can prevent steroid osteoporosis.