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目的:探讨急性冠状动脉综合征(ACS)患者循环血单核细胞Toll样受体4(TLR4)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hsCRP)的表达及其临床意义。方法:92例入选者分为4组:ACS组,48例(其中急性心肌梗死24例,不稳定型心绞痛24例);稳定型心绞痛组,12例;正常对照组,32例。比较各组间TLR4、TNF-α、hsCRP表达差异,分析TLR4与TNF-α、hsCRP的相关性。结果:ACS组TLR4、TNF-α、hsCRP的表达均较稳定型心绞痛组和正常对照组显著增高(P<0.05),TLR4与TNF-α、hsCRP呈正相关(P<0.05)。结论:ACS患者TLR4的表达增高,提示TLR4启动的免疫炎症机制参与冠心病的发生、发展。
Objective: To investigate the expression of TLR4, TNF-α and hsCRP in patients with acute coronary syndrome (ACS) significance. Methods: 92 patients were divided into four groups: ACS group, 48 cases (24 cases of acute myocardial infarction, 24 cases of unstable angina pectoris); 12 cases of stable angina pectoris group; 32 cases of normal control group. The differences of TLR4, TNF-α and hsCRP expression among different groups were compared, and the correlation between TLR4 and TNF-α and hsCRP was analyzed. Results: The expressions of TLR4, TNF-α and hsCRP in ACS group were significantly higher than those in stable angina group and normal control group (P <0.05). There was a positive correlation between TLR4 and TNF-α and hsCRP (P <0.05). Conclusion: The expression of TLR4 is increased in patients with ACS, suggesting that TLR4-initiated immunoinflammatory mechanisms are involved in the occurrence and development of coronary heart disease.