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目的探讨完全睡眠剥夺对额叶执行功能的反应抑制和冲突监控功能影响的神经生理机制。方法将某军校36名健康男性大学生(19±1.6岁)随机分为睡眠剥夺组(SD组)和非睡眠剥夺组(NSD组),SD组进行18 h的睡眠剥夺,而NSD组正常睡眠,两组被试在参加实验18 h后完成视觉Go/Nogo测验,并同时记录32导EEG。结果SD组较NSD组平均正确反应时明显延长(F(1,35)=4.45,P=0.04)。Nogo刺激与Go刺激比较诱发明显的Nogo-N2波(F(1,34)=11.86,P=0.002)和Nogo-P3波(F(1,34)=7.49,P=0.01);SD组与NSD组比较,其Nogo-N2波幅明显下降(F(1,34)=6.32,P=0.02),潜伏期明显延长(F(1,35)=6.36,P=0.02)。而Nogo-P3的平均波幅与潜伏期差异无统计学意义(P>0.05)。结论在18 h完全睡眠剥夺后,额叶执行功能中的冲突监控功能便明显受损,而反应抑制功能未见明显下降。
Objective To investigate the neurophysiological mechanism of the effect of complete sleep deprivation (ERP) on response suppression and conflict monitoring in frontal executive function. Methods Thirty-six healthy male college students aged 19 ± 1.6 years were randomly divided into sleep deprivation group (SD group) and non-sleep deprivation group (NSD group). SD group was subjected to sleep deprivation for 18 hours, Two groups of subjects completed the visual Go / Nogo test after participating in the experiment for 18 hours, and recorded 32-lead EEG at the same time. Results Compared with the NSD group, the average response time of SD group was significantly longer (F (1, 35) = 4.45, P = 0.04). Nogo-stimulated and Nogo-N2 wave induced significant Nogo-N2 wave (F (1, 34) = 11.86, P = 0.002) and Nogo-P3 wave Compared with the NSD group, the amplitude of Nogo-N2 decreased significantly (F (1, 34) = 6.32, P = 0.02) and latency was significantly longer (F (1, 35) = 6.36, P = 0.02). The mean amplitude and latency of Nogo-P3 had no significant difference (P> 0.05). Conclusion After 18 hours of complete sleep deprivation, the function of conflict monitoring in the frontal lobe was significantly impaired while the response inhibition function was not significantly decreased.