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在筛选具有抑制血小板凝集反应的新抗生素过程中,从日本土壤中分离到链霉菌OM-4842,其培养液中分离到一种新型异四酮抗生素OH-4842。把发酵液同从兔子血液中分离的富血小板血浆(PRP)混合,以凝血酶或二磷酸腺苷为血小板凝集剂,放在24
Streptomyces sp. OM-4842 was isolated from Japanese soil during the screening of new antibiotics with inhibition of platelet aggregation. A novel isocetone antibiotic OH-4842 was isolated from the culture medium. The broth was mixed with platelet-rich plasma (PRP) isolated from the blood of rabbits and thrombin or adenosine diphosphate was used as a platelet flocculant placed on a 24