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目的分析前列地尔注射液对心肾综合征(I型)患者血清肌钙蛋白T(c Tn T)、脑钠肽(BNP)及肌酸激酶同工酶(CK-MB)水平变化及肾血流谱的影响。方法将心肾综合征(Ⅰ型)患者144例随机分为研究组与对照组各72例,2组患者均给予常规综合治疗方案,研究组在对照组基础上给予前列地尔注射液治疗。分别于治疗前后抽取2组外周静脉血检测血清BNP、c Tn T及CK-MB水平。同时采用彩色多普勒超声仪检测肾脏血流动力学的参数。结果治疗后2组血清BNP、c Tn T及CK-MB明显低于治疗前,且研究组低于对照组;治疗后2组肾脏超声血流动力学参数D及V均高于治疗前,RI低于治疗前,且研究组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论前列地尔注射液可保护心肾综合征患者心肌细胞的再损伤,改善心脏功能,同时可减轻肾脏血流动力学阻力,增加肾脏血流灌注,起到保护肾脏功能的作用。
Objective To analyze the changes of serum cTnT, BNP and CK-MB in patients with cardio-renal syndrome (type I) and the effect of alprostadil Effect of blood flow spectrum. Methods One hundred and fourteen patients with cardio-renal syndrome (type I) were randomly divided into study group and control group, with 72 cases in each group. The two groups were given conventional comprehensive treatment. The study group was treated with alprostadil injection on the basis of the control group. Serum BNP, cTn T and CK-MB levels were measured before and after treatment in two groups of peripheral venous blood samples. At the same time, color Doppler ultrasound was used to detect the parameters of renal hemodynamics. Results After treatment, the levels of serum BNP, cTn T and CK-MB in the two groups were significantly lower than those before treatment, and the study group was lower than the control group. After treatment, the values of D and V in renal ultrasound were higher than those before treatment Lower than before treatment, and the research group changed more than the control group, the differences were statistically significant (P <0.05). Conclusion Alprostadil injection can protect cardiorenal syndrome re-injury of myocardial cells, improve cardiac function, reduce renal hemodynamic resistance and increase renal perfusion, play a role in protecting kidney function.