食物-药品间相互作用可通过许多不同机理发生,它们会导致药物的吸收速率和程度两者的改变。由于牛奶和其它乳制品钙含量高,很可能会减少胃肠道对可与二价金属离子形成微溶络合物药物的吸收,环丙沙星和其它喹诺酮可与不同金属离子键合形成不溶性络合物,因此我们对健康志愿者进行了对照实验来揭示其相互作用。采用三阶段随机交叉实验,每阶段间隔1周。女性4名,男性3名,(年龄21～30岁,体重65～82kg),禁食一夜后服用环丙沙星500mg,随即饮水300ml,全脂牛奶(含有钙360mg,镁33mg,蛋白质9.6mg,脂肪 Food-drug interactions can occur through many different mechanisms that lead to changes in both the rate and extent of drug absorption. Due to the high calcium content of milk and other dairy products, it is likely to reduce the gastrointestinal absorption of drugs that form sparingly soluble complexes with divalent metal ions, which may form insoluble with different metal ions Therefore, we conducted a controlled experiment in healthy volunteers to reveal their interaction. A three-stage randomized crossover experiment was used, one week apart. 4 females, 3 males (age 21-30 years old, weighing 65-82 kg), taking ciprofloxacin 500 mg overnight after fasting, drinking water 300 ml, whole milk (containing 360 mg of calcium, 33 mg of magnesium and 9.6 mg of protein ,fat