目的:研究新疆昆仑雪菊3种提取物在体外对α-葡萄糖苷酶活性的作用。方法:用传统水提法、水提醇沉法和大孔树脂纯化法,制备新疆昆仑雪菊3种提取物,并观察其对α-葡萄糖苷酶活性的影响。结果新疆昆仑雪菊的3种提取物体外均有抑制α-葡萄糖苷酶活性的作用,其中提取物Ⅲ的抑酶活性最强。结论:新疆昆仑雪菊3种提取物在体外具有抑制α-葡萄糖苷酶的活性。 Objective: To study the effect of three extracts of Xinjiang Kunluosuju on α-glucosidase activity in vitro. Methods: Three kinds of extracts from Xinjiang Kunluosuju were prepared by traditional water extraction method, water extraction and alcohol precipitation method and macroporous resin purification method, and their effects on α-glucosidase activity were observed. Results All of the three extracts from Xinjiang Kunluosuju inhibited the activity of α-glucosidase, and extract Ⅲ showed the strongest inhibitory activity against α-glucosidase. CONCLUSION: Three kinds of extracts from Xinjiang Kunluosuju inhibited the activity of α-glucosidase in vitro.