目的观察和分析血清β-人绒毛膜促性腺激素(β-h CG)、C-反应蛋白(CRP)和新嘌呤(Npt)水平与足月胎膜早破(PROM)孕妇合并羊膜感染的相关性。方法选取150例足月PROM孕妇作为研究对象,根据是否存在羊膜感染将纳入的孕妇分为感染组57例和非感染组93例。对两组孕妇产前的血清β-h CG、CRP、Npt水平进行检测和比较。结果感染组患者的血清β-h CG、CRP、Npt水平均高于非感染组,两组之间的差异均有统计学意义(t=4.128、6.713、3.925,均P<0.05);应用上述三种血清指标联合检测诊断足月PROM合并羊膜感染的敏感度均显著高于单独应用,差异有统计学意义(χ2=12.755、11.528、9.205,均P<0.05),而应用三种血清指标联合和单独应用一种指标检测诊断足月PROM合并羊膜感染的特异度差异无统计学意义(χ2=1.632,P>0.05);感染组孕妇的血清β-h CG水平与其血清CRP水平和Npt水平呈正相关关系(r=0.516、0.463,P<0.05),其血清CRP水平与血清Npt水平呈正相关关系(r=0.582,P<0.05)。结论足月PROM合并羊膜感染孕妇表现为血清β-h CG、CRP、Npt水平的显著升高,上述三种血清指标具有良好的相关性,而且进行联合检测时可提高诊断的敏感度,可作为诊断的辅助指标。 Objective To observe and analyze the relationship between serum β-hCG, CRP and Npt levels and amniotic infection in pregnant women with term premature rupture of membranes (PROM) Sex. Methods A total of 150 pregnant women with term PROM were enrolled in this study. According to the presence or absence of amniotic infection, pregnant women were divided into infection group (n = 57) and non-infection group (n = 93). Prenatal serum β-h CG, CRP, Npt levels were detected and compared in two groups of pregnant women. Results Serum levels of β-h CG, CRP and Npt in patients with infection were significantly higher than those in non-infected patients (t = 4.128, 6.713, 3.925, all P <0.05) The sensitivity of the combined detection of three serum markers in diagnosing term PROM combined with amniotic infection was significantly higher than that of single application (χ2 = 12.755,11.528,9.205, both P <0.05), but the combination of three serum indexes (Χ2 = 1.632, P> 0.05). The serum level of β-h CG in pregnant women with infection was positively correlated with serum CRP level and Npt level (R = 0.516,0.463, P <0.05). There was a positive correlation between serum CRP level and serum Npt level (r = 0.582, P <0.05). Conclusion The serum levels of β-h CG, CRP and Npt in pregnant women with full-term PROM and amniotic infection are significantly increased. The above three serum indexes have good correlation, and the sensitivity of diagnosis can be improved when combined with the test, which can be used as Aid for diagnosis.