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吡喹酮是治疗急性血吸虫病(以下称急血)的首选药,但在治疗过程中易致体温激惹,即类赫克斯海默反应(类JHR)和加重肝脏损害,特别是在小儿重型急血的治疗中更显突出。近年来,我们对重型急血患儿在服吡喹酮时并用糖皮质激素(简称激素),以期提高退热效果、减少类JHR发生率和改善肝脏毒性反应。现将结果报告如下。 1 临床资料与方法 1.1 病例选择本文70例急血患儿均符合《血吸虫病防治手册》的诊断、分型标准。以用吡喹酮合并短程激素治疗的患儿35例为治疗组,另以单用吡
Praziquantel is the drug of choice for the treatment of acute schistosomiasis (hereinafter referred to as “acute blood”), but is susceptible to body temperature exacerbation during treatment, ie, Class JHR and aggravating liver damage, especially in pediatrics Severe acute blood treatment more prominent. In recent years, we used praziquantel in combination with glucocorticoids (Hormone) to improve the antipyretic effect, reduce the incidence of JHR and improve liver toxicity. The results reported below. 1 Clinical data and methods 1.1 Case Selection This article 70 cases of children with acute cerebral hemorrhage are in line with “schistosomiasis prevention and treatment manual” diagnosis, classification criteria. Thirty-five children with praziquantel combined with short-hormones were treated with pirarubicin