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目的探讨转化生长因子(TGF)-β1在结直肠癌中的表达水平及与预后的关系。方法应用免疫组化技术检测52例结直肠癌病例术后标本中TGF-β1表达水平与血管内皮生长因子(VEGF)及临床病理特征间的相关性,Log-rank时序检验TGF-β1蛋白表达与生存时间的关系。结果TGF-β1表达为阴性和阳性者分别有11例和41例,而VEGF表达为阴性和阳性者分别有14例和38例,两者间有显著相关性(χ~2=0．633,P＜0．01),TGF-β1表达与Dukes分期(χ~2=19．866,P＜0.01)、淋巴结转移情况(χ~2=13．152,P＜0．01)也显著相关。本组病例总的3年生存率为49．1％,而TGF-β1表达为阴性和阳性者的3年生存率分别为69．2％和20．5％(χ~2=11．64,P＜0．01)。结论TGF-β1表达水平是影响结直肠癌患者预后的重要因素,临床上作为判断患者预后指标值得进一步研究。
Objective To investigate the expression of transforming growth factor-β1 (TGF-β1) in colorectal cancer and its relationship with prognosis. Methods Immunohistochemistry was used to detect the correlation between the expression of TGF-β1 and VEGF and clinicopathological features in 52 cases of colorectal cancer. Log-rank test was used to detect the expression of TGF-β1 The relationship between survival time. Results The positive and negative expressions of TGF-β1 were found in 11 cases and 41 cases, respectively. However, there were 14 cases and 38 cases with negative and positive VEGF expression (χ ~ 2 = 0.633, P <0.01). The expression of TGF-β1 was also significantly associated with Dukes stage (χ ~ 2 = 19.866, P <0.01) and lymph node metastasis (χ ~ 2 = 13.152, P <0.01). The overall 3-year survival rate was 49.1% in this group of patients, while the 3-year survival rates of those with negative and positive TGF-β1 expression were 69.2% and 20.5% (χ ~ 2 = 11.64, P <0.01). Conclusion The expression level of TGF-β1 is an important factor affecting the prognosis of patients with colorectal cancer. It is worth further studying clinically as a prognostic indicator of patients.