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目的 探讨早期诊断肾脏损伤的方法。方法 采用酶联免疫吸附法定量检测 ,尿微量白蛋白 (Alb) ,尿蛋白 1(UP1) ,尿视黄醇结合蛋白 (RBP) ,比色法测量N -乙酰 -β -D -葡萄糖甘酶 (NAG) ,Jaffe速率法测定尿肌酐。 结果 正常对照组尿AIb/cr∶1 93± 0 42 (mg/mmol) ,UP1/cr∶47 6 1± 5 86 (ug/mmol) ,RBP/cr∶2 4 41± 3 5 5 (ug/mmol) ,NAG/cr∶0 96± 0 5 8(u/mmol) ,尿蛋白定性阴性的糖尿病、高血压、系统性红斑狼疮及尿路感染患者尿Alb/cr、UP1/cr、RBP/cr及NAG/cr较正常对照组增高 (P <0 0 1)。尿蛋白定性阳性以上患者的Alb/cr、UP1/cr、RBP/cr及NAG/cr较阴性对照组显著提高 (P <0 0 1) ,单项或双项检测Alb、UP1、RBP或NAG这四项指标阳性率偏低。结论 联合检测尿Alb、UP1、RBP及NAG是诊断肾脏早期损伤的灵敏、可靠的实验室指标
Objective To explore the method of early diagnosis of kidney injury. Methods The levels of Alb, urinary protein 1 (UP1) and retinol - retinol binding protein (RBP) were measured by enzyme - linked immunosorbent assay (ELISA) and the ratio of N - acetyl - β - D - glucosidase (NAG), Jaffe rate method for the determination of urinary creatinine. Results In the normal control group, urinary AIb / cr: 93 ± 0 42 (mg / mmol), UP1 / cr:47 6 1 ± 5 86 (ug / mmol), RBP / Urinary Alb / cr, UP1 / cr, RBP / cr (NAG / cr: 96 ± 0 5 8 (u / mmol)), urinary protein-negative diabetes, hypertension, systemic lupus erythematosus and urinary tract infection And NAG / cr were higher than the normal control group (P <0.01). Alb / cr, UP1 / cr, RBP / cr and NAG / cr in patients with positive urine protein were significantly higher than those in the negative control group (P <0.01). Alb, UP1, RBP or NAG Item index positive rate is low. Conclusions The combined detection of urinary Alb, UP1, RBP and NAG is a sensitive and reliable laboratory index for the diagnosis of early renal injury