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目的本文回顾性分析青春期这一特殊年龄段鼻咽癌患者的特征及治疗效果,并涉及远期并发症。方法1975年7月至1992年12月,我院收治102例青春期鼻咽癌,Ⅲ、Ⅳ期占843%(86/102),全部接受放疗,其中6例N3患者接受化疗。结果全组局部控制率为759%(78/102),1、3、5年生存率分别为899%(86/102),607%(62/102),586%(60/102),Ⅲ、Ⅳa期5年生存率为524%(38/86)。6例N3患者配合化疗3例存活5年以上。远期并发症包括不育和发育迟缓和继发性闭经。远处转移是主要死亡原因。结论尽管青春期鼻咽癌患者初诊时多为局部晚期,但经根治性放疗后获得良好疗效。联用化疗可能增加疗效。由于许多患者获长期生存,远期并发症影响生存质量的问题就显得格外突出。
Objective This retrospective analysis of puberty in this special age group of patients with nasopharyngeal carcinoma characteristics and treatment, and involves long-term complications. Methods From July 1975 to December 1992, 102 cases of adolescent nasopharyngeal carcinoma were treated in our hospital. The patients in stage Ⅲ and Ⅳ accounted for 843% (86/102). All received radiotherapy. Six of them received chemotherapy. Results The overall rate of partial control was 75 9% (78/102). The 1, 3, 5-year survival rates were 899% (86/102), 607% (62/102), 586 % (60/102), Ⅲ, Ⅳa 5-year survival rate was 524% (38/86). 6 cases of N3 patients with chemotherapy in 3 cases survived more than 5 years. Long-term complications include infertility and stunting and secondary amenorrhea. Distant metastasis is the main cause of death. Conclusions Although adolescent nasopharyngeal carcinoma is mostly locally advanced when initially diagnosed, good curative effect is achieved after radical radiotherapy. Combined chemotherapy may increase the efficacy. Because many patients have long-term survival, long-term complications affect the quality of life is particularly prominent.