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目的:探讨CT导向下125I种子源植入治疗恶性肿瘤的安全性及临床疗效。方法:11例患者14个病灶行CT导向下125I种子源植入,其中原发肿瘤5例,转移瘤6例(9个病灶)。根据治疗计划系统(TPS)计算布源,在CT导向下将18.5~29.6MBq活度的125I种子源相隔1.0~1.5cm多层面植入肿瘤内。术后1~10个月复查CT观察种子源在瘤体内的分布、疗效及有无并发症。结果:随诊CT复查,14个病灶完全缓解(CR)5个;明显缓解(OR)7个;部分缓解(PR)2个;无效(P)0。治疗前后病灶平均大小分别为4.23cm和2.07cm(t=5.018,P<0.01)。未见急性并发症和治疗相关的放射损伤。结论:CT导向下125I种子源植入治疗恶性肿瘤是一种安全、有效的方法,近期疗效肯定。
Objective: To investigate the safety and clinical efficacy of CT guided 125I seed implantation in the treatment of malignant tumors. Methods: Fourteen lesions of 11 patients were implanted under CT guidance with 125I seeds, including 5 primary tumors and 6 metastatic tumors (9 lesions). According to the treatment plan system (TPS), the cloth source was calculated and CT-guided implantation of 125I seed source with the activity of 18.5-29.6MBq from 1.0-1.5cm multi-layer in the tumor. Postoperative 1 to 10 months to review the CT seed source in the tumor distribution, efficacy and complications. Results: Follow-up CT scans showed that 5 of 14 lesions were completely relieved (CR), 7 were significantly relieved (OR), 2 were partial remission (PR) and 0 was invalid. The average size of the lesions before and after treatment were 4.23cm and 2.07cm, respectively (t = 5.018, P <0.01). No acute complications or treatment-related radiation damage were seen. Conclusion: It is a safe and effective method to implant 125I seeds under CT guidance in the treatment of malignant tumor. The curative effect is definite in the near future.