论文部分内容阅读
目的探讨大环内酯类抗生素应用于婴幼儿支气管肺炎临床治疗中的效果,为临床应用提供参考依据。方法 220例婴幼儿支气管肺炎患儿,随机分为研究组和对照组,各110例。对照组给予红霉素治疗。研究组给予阿奇霉素序贯疗法治疗。比较两组患儿临床表现及不良反应发生情况。结果研究组显效74例、有效30例、无效6例,总有效率为94.55%;对照组显效44例、有效47例、无效19例,总有效率为82.73%;研究组总有效率高于对照组,差异具有统计学意义(P<0.01)。研究组不良反应发生率为1.82%,对照组为1.82%,比较差异无统计学意义(P>0.05)。两组均未出现严重不良反应,经对症处理症状消失。结论大环内酯类抗生素应用于婴幼儿支气管肺炎临床治疗中,效果肯定,而阿奇霉素序贯疗法效果更佳,不良反应少,用药安全性高,更适宜婴幼儿患儿,值得临床推广应用。
Objective To investigate the effect of macrolide antibiotics on the clinical treatment of bronchial pneumonia in infants and young children, and provide a reference for clinical application. Methods 220 infants and children with bronchial pneumonia were randomly divided into study group and control group, with 110 cases in each. The control group was given erythromycin treatment. Study group given azithromycin sequential therapy. The clinical manifestations and adverse reactions of the two groups were compared. Results The study group was effective in 74 cases, effective in 30 cases, ineffective in 6 cases, the total effective rate was 94.55%; the control group markedly effective in 44 cases, effective in 47 cases, ineffective in 19 cases, the total effective rate was 82.73%; study group total effective rate Control group, the difference was statistically significant (P <0.01). The incidence of adverse reactions was 1.82% in the study group and 1.82% in the control group, with no significant difference (P> 0.05). No serious adverse reactions occurred in both groups, and symptoms disappeared after symptomatic treatment. Conclusion The application of macrolide antibiotics in the clinical treatment of infantile bronchopneumonia has a positive effect, while the sequential therapy of azithromycin has better effect, less adverse reactions, high medication safety and is more suitable for infants and young children, which is worthy of clinical application.