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胎儿是一种成功的同种移植,但在移植免疫学上仍是一尚未解决的问题。Medawar(1953)指出,这可能是由于产母对胎儿抗原无反应力之故。母婴交换植皮的长期存活,说明胎生有一定程度的免疫惰性(P eer及Walker 1959)。出现于妊娠期中第一种明显免疫变化的证据是植物血凝素(phytohaemagglutinin,PHA)诱导淋巴细胞转化减少(Finn等1972;Purtilo等1972)。先前,Comings(1967)及Thiede等(1968)未能找出妊娠与非妊娠妇女淋巴细胞的PHA反应有任何差异。T-淋巴细胞数目减少的可能性曾被考虑到。Campion、Currey(1972)与Christiansen等(1976)证明,在妊娠期排成玫瑰花瓣样的T-淋
The fetus is a successful allograft, but remains an unresolved issue in transplantation immunology. Medawar (1953) pointed out that this may be due to mother’s unresponsiveness to fetal antigens. The long-term survival of maternal-to-infant skin grafts shows some degree of immunological inertia (Peyer & Walker 1959). Evidence of the first overt immunological changes that occur during pregnancy is that phytohaemagglutinin (PHA) induces a decrease in lymphocyte transformation (Finn et al. 1972; Purtilo et al. 1972). Previously, Comings (1967) and Thiede et al. (1968) failed to find any difference in the PHA response of lymphocytes in pregnant and nonpregnant women. The possibility of a decrease in the number of T-lymphocytes has been taken into account. Campion, Currey (1972) and Christiansen et al. (1976) demonstrated that rose petal-like T-rashes