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目的分析探讨多塞平联合奥美拉唑、蒙脱石对治疗慢性胃炎患者的临床疗效,以期为临床治疗提高参考。方法以2008年5月-2012年3月我科收治的303例经胃镜检查确诊为慢性胃炎的患者为研究对象。根据是否加用多塞平治疗将患者随机分为两组:其中治疗组156例,在奥美拉唑联合蒙脱石治疗的基础上加用多塞平,对照组147例,根据患者的临床症状给予不同剂量的奥美拉唑和蒙脱石治疗。4周后观察比较两组的临床疗效以及焦虑和抑郁改善情况。结果治疗组患者的临床疗效显著高于对照组(P<0.05),且与治疗前相比,焦虑和抑郁情况得到明显的改善(P<0.05)。结论应用多塞平联合奥美拉唑、蒙脱石能有效缓解患者的焦虑和抑郁情绪,提高患者对疾病治疗的信心,进而提高慢性胃炎患者的临床治疗效果。
Objective To investigate the clinical efficacy of doxepin combined with omeprazole and montmorillonite in the treatment of patients with chronic gastritis in order to improve the reference for clinical treatment. Methods From May 2008 to March 2012, 303 cases of chronic gastritis diagnosed by gastroscopy were enrolled in this study. According to whether or not to add doxepin, the patients were randomly divided into two groups: 156 cases in the treatment group, the combination of omeprazole and montmorillonit on the basis of the use of doxepin, the control group of 147 cases, according to the patient’s clinical Symptoms given different doses of omeprazole and montmorillonite treatment. After 4 weeks, the clinical efficacy and the improvement of anxiety and depression in the two groups were observed and compared. Results The clinical efficacy of the treatment group was significantly higher than that of the control group (P <0.05), and anxiety and depression were significantly improved (P <0.05) compared with those before treatment. Conclusion Combination of doxepin and omeprazole, montmorillonite can effectively alleviate anxiety and depression in patients with mood and improve patient confidence in the treatment of disease, and thus improve the clinical treatment of patients with chronic gastritis.