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目的 探讨不能切除原发性肝癌经肝动脉化疗栓塞 (TACE)后Ⅱ期手术切除的临床疗效。方法 36例不能切除的原发性肝癌经 1～ 6次TACE治疗后获Ⅱ期手术切除 ,其中 2 2例手术切除后再行TACE治疗。化疗药物选用表阿霉素 (EADM )、丝裂霉素 (MMC)、甲酰四氢叶酸钙 (CF)、5 氟尿嘧啶 ( 5 FU)。结果 TACE治疗后有效率 (CR +PR)为 5 5 6 % ,中位生存期为 34个月。 1、2、3、4、5年累积生存率分别为 94 0 %、82 3%、70 9%、5 3 2 %、5 3 2 %。结论 不能切除的原发性肝癌行TACE ,肿瘤缩小后Ⅱ期切除是延长患者生存期的有效方法 ,Ⅱ期切除后肝内复发转移再行TACE治疗仍能获得较好疗效 ,延长生存期
Objective To investigate the clinical effect of resection of primary hepatocellular carcinoma (HCC) treated with stage Ⅱ transcatheter arterial chemoembolization (TACE). Methods Totally 36 unresectable primary hepatocellular carcinoma (HCC) were treated with TACE after 1 to 6 times of TACE. Twenty-two patients underwent TACE after resection. Chemotherapeutic drugs used epirubicin (EADM), mitomycin (MMC), leucovorin (CF), 5-fluorouracil (5 FU). Results After TACE treatment, the effective rate (CR + PR) was 55.6% and the median survival time was 34 months. The cumulative survival rates at 1, 2, 3, 4 and 5 years were 94 0%, 82 3%, 70 9%, 53 32% and 53 32% respectively. Conclusion TACE of unresectable primary hepatocellular carcinoma is an effective method to prolong the survival of patients after TCC resection. TACE treatment of recurrence and metastasis of intrahepatic metastasis after Ⅱ resection can still get better curative effect and prolong survival