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目的观察口服米非司酮配伍米索前列醇用于终止妊娠12～16周的临床效果,旨在寻找一种安全、有效、可靠、省时、出血量少、并发症少的方法。方法选择妊娠12～16周要求终止妊娠而无禁忌症的孕妇100例,第一天晚上口服米非司酮150mg,服药前后2h空腹,第二天早晨空腹将米索前列醇0.2mg碾碎后置于阴道后穹窿,用药后卧床休息2h,观察用药后宫缩情况、妊娠物排出时间、阴道出血量及药物不良反应等。结果米非司酮配伍米索前列醇用于终止妊娠12～16周100例中有效100例,有效率100%。结论口服米非司酮配伍米索前列醇终止妊娠12～16周是一种安全、有效、可靠的方法,具有成功率高、痛苦小、出血量少、并发症少等优点,值得临床推广应用。
Objective To observe the clinical efficacy of oral mifepristone and misoprostol for terminating pregnancy from 12 to 16 weeks, aiming at finding a safe, effective, reliable, time-saving, less bleeding and less complication. Methods 100 pregnant women who required termination of pregnancy and no contraindications during the first 12 days of gestation were enrolled in this study. On the first night, 150 mg of mifepristone was given orally, 2 h before and after fasting, and 0.2 mg of misoprostol was crushed in the morning after fasting Placed in the vaginal fornix, bed rest 2h medication after observation of contractions, pregnancy discharge time, vaginal bleeding and adverse drug reactions. Results Mifepristone with misoprostol for termination of pregnancy 12 to 16 weeks in 100 cases, 100 cases, the effective rate of 100%. Conclusion oral mifepristone with misoprostol to terminate the pregnancy 12 to 16 weeks is a safe, effective and reliable method with high success rate, little pain, less blood loss, fewer complications, worthy of clinical application .