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目的探讨美托洛尔对不稳定型心绞痛患者血清IL-6和C反应蛋白(CRP)活性的影响。方法不稳定型心绞痛患者62例,分为美托洛尔治疗组(A组)31例,不使用美托洛尔组(B组)31例,健康对照组30例。检测各组入院即刻2、4 h、出院前血清CRPI、L-6的水平。结果(1)A组和B组血清CRPI、L-6水平明显高于对照组(P<0.001)。(2)血清CRP水平B组明显高于A组;血清IL-6水平入院时即刻2、4 h B组较A组明显升高,出院时IL-6水平在这两组相似。结论炎症反应在心绞痛发生、发展中起重要作用,β-受体阻滞剂具有降低不稳定型心绞痛患者IL-6、CRP的水平的作用。
Objective To investigate the effects of metoprolol on serum IL-6 and C-reactive protein (CRP) activity in patients with unstable angina pectoris. Methods Sixty-two patients with unstable angina were divided into metoprolol treatment group (group A), 31 cases without metoprolol group (group B), 31 cases and healthy control group (n = 30). The levels of serum CRPI and L-6 before discharge in hospital were detected immediately after 2,4 h admission. Results (1) Serum levels of CRPI and L-6 in group A and group B were significantly higher than those in control group (P <0.001). (2) Serum CRP level in group B was significantly higher than that in group A; IL-6 level in group B was significantly higher than that in group A immediately after admission at 2,4 and 2 h after admission, and IL-6 levels were similar between the two groups at discharge. Conclusion The inflammatory reaction plays an important role in the development of angina pectoris. Β-blocker can reduce the levels of IL-6 and CRP in patients with unstable angina pectoris.