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目的 :比较切割球囊血管成形术 (CBA)与普通球囊血管成形术 (BA)对血清IL 6和C反应蛋白 (CRP)浓度的影响 .方法 :65例拟行冠脉介入治疗的不稳定型心绞痛患者 ,随机分为 2组 ,分别接受CBA或BA ,球囊扩张后均放置支架 .分别于术前、术后即刻、2h和 6h抽取冠状静脉窦血样测定血清IL 6的浓度 ;另于术前、术后 6,2 4和 4 8h抽取肘静脉血样 ,测定血清CRP的浓度 .血清IL 6和CRP的浓度均以ELESCA双抗体夹心法进行测定 .结果 :两组患者临床特征及靶病变情况无显著差异 .CBA组的球囊最大充盈压及支架置入压力明显低于BA组 (P <0 .0 1) .BA组IL 6浓度在术后即刻开始高于CBA组 ,术后 2h和 6h差异进一步增大 (P <0 .0 1) .BA组的CRP浓度在术后 6,2 4和 4 8h都明显高于CBA组 (P <0 .0 1) .结论 :CBA以及联合支架置入术对不稳定型心绞痛患者血清IL 6和CRP浓度的影响均小于BA或其联合支架置入术 ,这可能是前者通过减轻对炎症反应的影响 ,减少RS及心血管事件发生的机制之一
Objective: To compare the effects of CBA and BA on serum IL-6 and C-reactive protein (CRP) concentrations.Methods: 65 cases of unstable coronary artery Type angina pectoris patients were randomly divided into two groups, receiving CBA or BA respectively, after balloon dilatation were placed stents were measured before surgery, immediately after surgery, 2h and 6h extraction of coronary venous sinus blood serum IL 6 concentration; the other in The cubital vein blood samples were taken at 6, 24 and 48 h after operation, and the concentrations of serum CRP were measured.The concentrations of IL 6 and CRP in serum were measured by ELESCA double antibody sandwich method.Results: The clinical features and target lesions There was no significant difference.CBA group balloon filling pressure and stent placement pressure was significantly lower than BA group (P <0.01) .BA group IL 6 concentration immediately after the start than CBA group, 2h (P <0.01) .Compared with CBA group (P <0.01), the CRP concentration in BA group was significantly higher than that in CBA group at 6, 24 and 48 hours after operation The effect of stenting on serum IL-6 and CRP levels in patients with unstable angina was less than that of BA or stenting, which may be Who by mitigating the effects of the inflammatory response, reducing the RS and one of the mechanisms of cardiovascular events