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目的应用一新的动脉标记技术,探讨其描述VX2肿瘤高低血流灌注区特征的可行性。方法将VX2肿瘤接种于17只新西兰白兔双侧大腿肌肉内,采用附加射频的流敏交替反转回波技术,在自旋回波图上预估肿瘤的活性,通过减影法获取血流灌注图像,对肿瘤存活区、肿瘤坏死区和肌肉区作感兴趣区(ROI)分析,应用t检验分析感兴趣区资料。结果自旋回波图像在17只免34条大腿中显示了30个肿瘤区,成功地获取了所有的血流灌注图像。肌肉区的信号强度平均值是50±08,肿瘤存活区的信号强度平均值是117±39(左侧)和110±31(右侧),肌肉与两侧肿瘤存活区的差异有统计学意义(P<0001),表明肿瘤存活区为高灌注区域,但两侧肿瘤存活区的差异无统计学意义(P=059)。肿瘤坏死区的信号强度平均值明显低于肌肉区(P<0001)。结论附加射频的流敏交替反转回波序列是一简便的描述肿瘤血流灌注特征的技术,便于观察肿瘤富血管区,从而有利于肿瘤术前栓塞等计划的制定。
Objective To explore the feasibility of describing the characteristics of perfusion region in VX2 tumor by applying a new arterial marker technique. Methods VX2 tumors were inoculated into the muscle of bilateral thighs of 17 New Zealand white rabbits. The flow-sensitive alternating-echo technique with additional radiofrequency was used to estimate the tumor activity on the spin echo map. The blood perfusion was obtained by subtraction Images were taken for ROI analysis of tumor-surviving area, tumor necrosis area and muscle area. The t-test was used to analyze the ROI data. Results Spin-echo images showed 30 tumor areas in 17 of the 34 free thighs and successfully acquired all perfusion images. The average signal intensity of the muscle region was 50 ± 08, and the average signal intensity of the tumor survival region was 117 ± 39 (left) and 110 ± 31 (right), the difference between the muscle and the tumor survival area on both sides was statistically significant (P <0.0001), indicating that the tumor survival area is a high perfusion area, but the tumor survival area on both sides showed no significant difference (P = 059). The average signal intensity of tumor necrosis area was significantly lower than that of muscle area (P <0001). Conclusions The addition of RF-based alternating-current reversed-flow echo is a simple and convenient technique to describe the characteristics of tumor perfusion, which facilitates the observation of the tumor-rich vascular region and is conducive to the planning of preoperative embolization of tumor.