目的探讨鼻腔鼻窦恶性T细胞淋巴瘤的临床诊断。方法对16例鼻腔鼻窦恶性T细胞淋巴瘤患者的临床资料进行回顾性分析,16例患者中均行放疗及化疗治疗。结果16例患者有4例经1次病理活检确诊,其余12例经2次或2次以上病理活检确诊,7例误诊为其他疾病,随访6例,均在6～30个月内死亡。结论鼻腔鼻窦恶性T细胞淋巴瘤容易被误诊,必须根据临床病史、经验、影像及病理学等检查,才能作出准确的诊断。 Objective To investigate the clinical diagnosis of nasal sinus malignant T cell lymphoma. Methods The clinical data of 16 patients with malignant T-cell lymphoma of the nasal cavity were analyzed retrospectively. All the 16 patients underwent radiotherapy and chemotherapy. Results Four of the 16 patients were diagnosed by pathological biopsy. The remaining 12 patients were diagnosed by two or more pathological biopsies. Seven patients were misdiagnosed as other diseases. Six patients were followed up, all of whom died within 6-30 months. Conclusion Nasal sinus malignant T cell lymphoma is easily misdiagnosed, and must be based on clinical history, experience, imaging and pathology and other tests to make accurate diagnosis.