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大鼠蛛网膜下腔置管,辐射热甩尾法测痛。蛛网膜下腔注射吗啡(2ug/rat)、苯哌利啶(1ug/ rat)、或可乐定(5ug/rat)、甩尾阈略有提高;蛛网膜下腔注射吗啡或苯哌利啶加可乐定,痛阈明显提高, 其程度超过分别注药的相加。大鼠皮下注射小剂量吗啡(1mg/kg)或苯哌利啶(40ug/kg),痛阈提高有 限,但皮下注药的同时,蛛网膜下腔注射可乐定(5ug/rat),痛阈明显提高,镇痛持续时间延长。因而,蛛 网膜下腔或皮下注射小剂量阿片类药和蛛网膜下腔小剂量可乐定,其镇痛呈协同。
Rats subarachnoid catheter, radiation heat flick method to measure pain. Subarachnoid injection of morphine (2ug / rat), lperitoneal (1ug / rat), or clonidine (5ug / rat), tail flick margin slightly increased; subarachnoid morphine or injection of piperadine plus Clonidine, pain threshold increased significantly, the degree of more than the sum of the injection. Subcutaneous injection of a small dose of morphine (1 mg / kg) or phenylephrine (40 ug / kg) in rats resulted in a limited increase in pain threshold, but subcutaneous injection of clonidine (5 μg / rat) Significantly increased analgesic duration extended. Thus, subarachnoid or subcutaneous injection of low-dose opioids and subarachnoid low-dose clonidine, the analgesic synergistic.