野生型p53基因的缺失对肿瘤的发生有着重要的意义。在人类所有肿瘤中大概有50%的p53基因发生突变,几乎所有肿瘤p53基因的缺陷与肿瘤的发生发展和转移有关。最近Patricia等发现,突变型P53蛋白的表达可以促进肿瘤的侵袭,使肿瘤迁移的定向性丢失,并提高肿瘤转移行为的能力。这些突 The loss of wild-type p53 gene is of great importance to tumorigenesis. Approximately 50% of all human cancers have mutations in the p53 gene. Almost all tumor p53 defects are associated with tumor development and metastasis. Recently, Patricia et al. Found that the expression of mutant P53 protein can promote tumor invasion, loss of orientation of tumor migration, and increase the ability of tumor metastasis. These sudden