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人乳头瘤病毒(HPV)16/18型和宫颈癌的关系密切,在宫颈癌发生发展中起重要作用。HPV16最易导致宫颈鳞癌,HPV18最易导致宫颈腺癌。HPV16/18致癌机制主要是通过病毒基因组中致癌蛋白E6,E7与抑癌基因p53和pRb结合,E6抑制p53的活性,E7灭活Rb基因的活性,致肿瘤发生。常用的HPV检测方法有原位杂交法(ISH)、第二代杂交捕获试验(HCⅡ)、聚合酶链反应(PCR)等。针对HPV16/18的预防和治疗性疫苗成为研究热点。综述HPV16/18型和宫颈癌关系研究进展。
Human papillomavirus (HPV) type 16/18 is closely related to cervical cancer and plays an important role in the development of cervical cancer. HPV16 most likely to cause cervical squamous cell carcinoma, HPV18 most likely to cause cervical adenocarcinoma. The oncogenic mechanism of HPV16 / 18 is mainly through the combination of the oncogenic proteins E6 and E7 in the viral genome and the tumor suppressor p53 and pRb, E6 inhibits the activity of p53 and E7 inactivates the activity of Rb gene and causes tumorigenesis. Commonly used HPV detection methods are in situ hybridization (ISH), second generation hybridization capture test (HC Ⅱ), polymerase chain reaction (PCR) and so on. Prevention and curative vaccines against HPV16 / 18 have become the research hotspot. Review of Research Progress on the Relationship between HPV16 / 18 and Cervical Cancer.