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棉酚的男性避孕作用和副作用（如：不可逆性不育和低血钾症）均为男性学学者所熟悉，其副作用使棉酚至今不能成为广泛应用的男性避孕药。本文试图通过减低棉酚的起效量和维持量以减少或避免副作用的发生。结果发现：每天服用１０ｍｇ或１２．５ｍｇ，待精子密度降为≤４００万／ｍｌ时，改服维持量（隔天１０ｍｇ，或１２．５ｍｇ）均有避孕效果，但起效期较长。服药期间血清ＦＳＨ、ＬＨ和睾酮水平无明显变化，尿β－２ＭＧ和ＮＡＧ以及血钾也无明显异常，服药者更无低血钾症状出现。服药对象的女方无妊娠。
Male contraceptives and side effects of gossypol (eg, irreversible infertility and hypokalemia) are familiar to male scholars, with the side effects that gossypol has so far failed to become a widely used male contraceptive. This article attempts to reduce or prevent the occurrence of side effects by reducing the amount of gypsum produced and maintained. The results showed that: taking 10mg or 12.5mg daily, until the sperm density dropped to ≤ 4 million / ml, change the maintenance dose (every other day 10mg, or 12.5mg) have contraceptive effect, but a longer period of onset. Serum FSH, LH and testosterone levels did not change significantly during the medication, urinary β-2MG and NAG, and serum potassium did not show significant abnormalities, medication more hypokalemic symptoms appear. The woman who takes the medication has no pregnancy.