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为探讨胆碱能神经功能和胃窦部幽门螺杆菌（Ｈｐ）感染与慢性胃炎（ＣＧ）、消化性溃疡（Ｐｕ）的关系，测定７６例慢性胃炎和消化性溃疡患者全血和胃液乙酰胆碱（Ａｃｈ），并检测胃窦部幽门螺杆菌的感染指标，同时测定１８例健康对照组全血Ａｃｈ。结果：Ａｃｈ在ＣＧ、Ｐｕ和对照组间、不同胃炎程度间、活动性与非活动性胃炎间以及Ｈｐ阳性与阴性间均无显著性差异；Ｈｐ感染率在Ｐｕ患者高于ＣＧ、活动性高于非活动性胃炎，并随胃炎程度加重而增高；清除Ｈｐ后Ｐｕ愈合、胃炎改善。提示Ｈｐ感染是ＣＧ和Ｐｕ的病因之一，胆碱能神经功能紊乱可能不是其主要病因。
In order to explore the relationship between cholinergic function and H.pylori infection and chronic gastritis (CG) and peptic ulcer (Pu) in gastric antrum, 76 patients with chronic gastritis and peptic ulcer were treated with whole blood and gastric juice of acetylcholine Ach), and detect the infection index of Helicobacter pylori in gastric antrum. At the same time, 18 cases of Ach in whole blood of healthy control group were measured. Results: There was no significant difference of Ach between CG, Pu and control group, between different degree of gastritis, active and inactive gastritis, and between Hp positive and negative; Hp infection rate was higher in Pu patients than CG, high activity In non-active gastritis, and increased with the degree of gastritis increased; Pu Hp clearance after healing, gastritis improved. Tip Hp infection is one of the causes of CG and Pu, cholinergic neurological disorders may not be the main cause.